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Description

In normal physiological conditions, the organelle utilizes a variety of mechanisms to tightly regulate ROS (25)

43: 26558 Tariq M, Morais C, Sobki S, et al

3f), confirming impaired fatty acid oxidation under sorafenib treatment

Abstract Effective cancer therapeutics for brain tumors must be able to cross the blood-brain barrier (BBB) to reach the tumor in adequate quantities and overcome the resistance conferred by the local tumor microenvironment

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Cystine starvation has been shown to impede TNBC growth, which affects stem cell properties and chemotherapy resistance in TNBC (27), thereby promoting TNBC cell ferroptosis through activation of the general control nonderepessible 2-eukaryotic translation initiation factor 2 subunit 1-activating transcription factor 4-CHAC1 pathway through the specific cytosolic GSH degradation enzyme CHAC1 (28)