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In neurodegenerative diseases, persistent DNA damage overwhelms the repair mechanisms, causing genomic instability and triggering apoptotic pathways [129,130]

Kouzegaran S, Zamani MA, Faridhosseini R, Rafatpanah H, Rezaee A, Yousefzadeh H, et al

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The research compounds sector has experienced notable changes during recent years

In normoxia, hydroxylation of HIF- by PHDs enables its interaction with pVHL (von Hippel-Lindau protein) and targets subunits for ubiquitination and proteasomal degradation [140]