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In the absence of amino acids such as cystine, cells promote translation of ATF4 via the general control non-repressor 2 (GCN2) -eukaryotic initiation factor (eIF2a) signaling pathway, which promotes transcription of genes involved in amino acid metabolism and stress response, including SLC7A11, enabling cells to cope with amino acid starvation

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Smart food combinations can help your body stay resilient and well-defended especially when consistently included in your diet

The potential of these types of compounds as kidney-selective antitumor prodrugs has been demonstrated in tissue distribution experiments

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