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Treatment-resistant depression complicates patient care and increases health care burden.3,8 Although there is no agreed-upon clinical definition for treatment-resistant depression, the working definition is an inadequate response to at least 2 antidepressant trials, with agents of differing classes of adequate dose and duration and treatment adherence.3 Table 1 describes in greater detail a system of staging treatment-resistant depression.9 The primary diagnosis of MDD should be confirmed in patients who appear to have treatment-resistant depression

Aim to sip water throughout the day rather than waiting until you feel thirsty

A recent paper compared zonulin levels with colonic paracellular permeability using Ussing chambers in IBS patients and found no correlation [79]

In many cases, we pair peptides like CJC-1295 or Sermorelin with GLP-1 medications (semaglutide, tirzepatide) for enhanced metabolic results

As obesity is a major risk factor for various health complications, the introduction of Tirzepatide represents a significant advancement in the treatment landscape for individuals struggling with both diabetes and obesity

The economic case for reducing diagnostic delays is compelling