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Cell-line Selectivity Improves the Predictive Power of Pharmacogenomic Analyses and Helps Identify NADPH as Biomarker for Ferroptosis Sensitivity

ALA: Alpha-Linolenic Acid,GPX4: Glutathione Peroxidase 4, GSH: glutathione, CISD2: CDGSH, Iron Sulfur Domain 2, SLC7A11: Solute Carrier Family 7 Member 11, IGF2BP3: Insulin-Like Growth Factor 2 mRNA, Binding Protein 3, RM: Recurrent miscarriage, EMT: Epithelial-Mesenchymal Transition, HIF1: Hypoxia-Inducible Factor 1 Alpha, lnc-HZ06: Long Non-coding RNA HZ06, NCOA4: Nuclear Receptor Coactivator 4, lncRNA: Long Non-coding RNA, ROS: reactive oxygen species, TP53: Tumor Protein 53, EZH2: Enhancer of Zeste Homolog 2, TIMP1: Tissue inhibitor matrix metalloproteinase 1, SLC3A2: Solute Carrier Family 3 Member 2, GABARAPL2: Gamma-aminobutyric acid receptor-associated protein-like 2

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Explainable AI for CHO cell culture media optimization and prediction of critical quality attribute

10.1515/bchm2.1930.190.3-6.93 Hoppe Seylers Zeitschrift Fur Physiologische Chemie 177 WalleyK

This suggests that rhizobia use GSH to mitigate the stress induced by the activation of plant defenses in these mutants