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Apoptosis Inducing Factor Acts as a Suvival Factor in Acute Myelogenous Leukemia through Mitochondrial Complex 1

Deficiency in Mfn1 or Mfn2 expression disrupts mitochondrial structure, promoting cardiomyocyte hypertrophy and heart failure, and significantly inhibiting the expression of mitochondrial biogenesis-related proteins (PGC-1 and Nrf-1) [71]

However, intracellular GSH content alone cannot explain differences in sensitivity as there was no correlation observed between intracellular concentrations of low molecular weight thiols including GSH and the sensitivity toward reuterin of various bacterial strains 23

Holmer, S.M., Evans, K.S., Asfaw, Y.G., Saini, D., Schell, W.A., Ledford, J.G., Frothingham, R., Wright, J.R., Sempowski, G.D

Most of these proceed via wet chemistry methods with the use of highly reactive reducing agents such as sodium borohydride, hydrazine etc

Valls-Pedret C, Lamuela-Raventos RM, Medina-Remon A, et al