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Whether the observed reduction in expression levels led to reduced protein levels remains to be investigated

Discussion This systematic review gives a summary of current knowledge, and literature available reflecting clinical, genetic, and therapeutic aspects of IGS and gives us an idea about heterogeneity and commonality across cases reported so far

Nitric oxide regulates mitochondrial fatty acid metabolism through reversible protein S -nitrosylation

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For instance, studies with Manuka and Tualang honeys show that they can arrest breast and colorectal carcinoma cells at G0/G1 or G2/M checkpoints by modulating cyclin-dependent kinases (CDK4/6) and elevating p21/WAF1 ( Figure 1 Experimental evidence from both in vitro and in vivo models supports honeys role in modulating cell cycle progression