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Evidence has shown their capability to increase the expression of NRF2 target genes in cellular and in vivo models of chronic obstructive pulmonary disease (COPD) [298], and to interfere with the direct PPI between KEAP1 and NRF2 or the PPI between KEAP1 and CUL3 [299, 300]

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on the other hand, reducing excessive ROS in immune cells can improve their function and persistence

Discussion Metabolic profiling and the absence of putative genes encoding important enzymes of the Embden-Meyerhof-Parnas and Entner-Doudoroff pathway suggest that, in contrast to the closely related H

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Researchers reported that NNMT inhibition affected senescent muscle-stem-cell activity and selected measures of regenerative capacity after experimental injury