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doi: 10.1097/MD.0000000000032653 56 VincentAMCallaghanBCSmithALFeldmanEL

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During his research, Sterne found metformin to be the most efficacious due to its ability to lower glucose levels with minimal adverse effects and its reduced toxicity at higher dosages compared to those of other guanidine-based compounds

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Currently, there is still inadequate evidence to illustrate its impact on the polarization phenotype of COPD macrophages