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The trial randomised 380 subjects on stable treatment with levodopa without motor complications to double-blind adjunct therapy with either 50 mg of opicapone or placebo for 24 weeks and offered transition into a 52-week extension on open-label treatment with 50 mg of opicapone for all participants [130]

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Chronic mouth breathing during sleep can reduce saliva production by up to 40%, continuously drying the oral mucosa and triggering thirst

Daarbij werd ook het stikstofmonoxidesysteem benvloed, een regulerend mechanisme dat zowel de doorbloeding als de immuunrespons aanstuurt