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Using tap water is research malpractice

When Poldip2 is deficient, it induces protein O-GlcNAcylation and inhibits the ubiquitin-proteasome system through metabolic reprogramming (TCA cycle inhibition, glycolytic activity, increased HBP activity), resulting in the accumulation of polyubiquitinated proteins in the nucleus to maintain the stability of SRF, ultimately leading to VSMC differentiation [136]

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A genetically encoded device for transcriptome storage in mammalian cells Science