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In this study, none of the sweeteners applied to the human lymphocytes had any effect on cell-mediated immunity.] (b) Experimental systems Non-human mammals in vivo In NC/Nga mice in which atopic dermatitis had been induced by dinitrofluorobenzene, aspartame (0.5 g/kg or 0.5 mg/kg) administered daily for 9 days (from day 9 to day 18) inhibited inflammatory cells (including eosinophils, mast cells, and CD4+ T-cells) and suppressed the expression of cytokines (IL-4 and IFN) and total serum IgE levels relative to mice exposed to dinitrofluorobenzene only (Kim et al., 2015a)

[DOI] [PMC free article] [PubMed] [Google Scholar] 78.Janakiram NB, Mohammed A, Madka V, Kumar G, Rao CV