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Traish, Zitzmann and Garcia-Segura declare they have no conflict of interest

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

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The altered expression of proteoglycans and their glycosaminoglycan chains affects the activation of tyrosine kinase receptors, while changes in glycosylation of growth factor receptors and gangliosides modulate signal transduction pathways, enhancing tumor growth and proliferation