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Drug Design, Development and Therapy 9:2485-2499

Therapies that rely on scaffold-free cellular approaches, such as ACI, are not designed to handle these mechanical burdens early post-surgery, and thus, utilizing scaffolds with improved bulk mechanical properties could increase efficacy of treatment and promote earlier return to normal activity in these knees

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Do B12 shots hurt

Unless, of course, the clinical picture says otherwise

This suggests an intrinsic degradation pathway independent of withdrawal frequency, though the magnitude is small enough that the samples remained above the literature-supported effectiveness floor