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4.1.2 Inclusion and exclusion criteria We included clinical studies that satisfied the following criteria: (a) Study participants were diagnosed with elderly diabetes, with or without diabetes nephropathy, diabetes peripheral neuropathy, diabetes retinopathy, diabetes cardiomyopathy, diabetes gastroparesis, diabetes foot, cognitive impairment, osteoporosis, sarcopenia, coronary heart disease, and arterial sclerosis

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Over the years, many efforts have been made to scout the potency and safety of plant medications and to clarify the cellular and molecular mechanisms that explain the therapeutic effect of these plants

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However, poorly soluble polar and non-polar molecules will require organic solvents such as DMSO [8]