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Consistent with its proposed, exclusive role in the maturation of [4Fe-4S] clusters, ABCB7 deletion has little effect on mitochondrial [2Fe-2S] + protein activity but results in functionally deficient cytosolic and nuclear [4Fe-4S] 2+ proteins ( + cluster ([2Fe-2S](SG) 4 ) is the natural substrate for ABCB7, and is thus, represents the [2Fe-2S] + cluster that is utilized by the CIA machinery ( 2+ cluster formation to occur

When using the ICD-11, symptoms of inattention or symptoms of hyperactivity and impulsivity or a combination of both must persist at least for 6 months before a diagnosis of ADHD is made

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This implies that females are more commonly and, possibly, severely affected than males, and, in familial cases, the disease is more frequently transmitted by an affected mother

As shown in Figures 5A,B, cisplatin exposure induced a significant loss of MMPindicative of mitochondrial depolarization and early bioenergetic impairment