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Ethics declarations Acknowledgements This work was undertaken as part of UK Biobank project application ref 56653 Pharmacogenomics to improve drug efficacy and safety

Vitamin B12 is essential for producing red blood cells and maintaining a healthy nervous system

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309,315 Therapies targeting endothelial function are being explored to prevent or mitigate DPN progression (Fig

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Pyridoxine Hydrochloride (a form of Vitamin B6) - essential for the maintenance of a healthy immune system and as an essential component of various metabolic pathways