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It is thought to arise from a combination of microvascular dysfunction, chronic inflammation, and increased interstitial pressure that may compress peripheral nerves

For instance, elevated glycolysis-induced lactylation of SRY-related high mobility group-box 9 (SOX9), a transcription factor belonging to the SOX family, promotes stemness, migration, and invasion of NSCLC cells

L., Dai, Y

Acta Chin Med Pharmacol

7) Hypothyroidism Several studies have found higher homocysteine levels in hypothyroidism [30, 31, 32]