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Chemical Information: Compound Name: Dihexa

A.RokicinskiM

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24 h) inhibits the activation of the NLRP3 inflammasome in TNF--injured human podocytes (HPC) in a Parkin-dependent manner [1]

Endoplasmic reticulum stress sensing in the unfolded protein response

Animal studies further confirmed that colonization with Escherichia coli upregulates lupus-associated serum biomarkers and exacerbates glomerular lesions in MRL/lpr mice, providing mechanistic support for the associations observed in humans, though validation in clinical settings is still required [26]