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Rapid urbanization is intensifying this trend, as city dwellers actively seek nutritional interventions to combat oxidative stress, environmental pollution exposure, and immune system challenges

First-generation activators, including natural isothiocyanates like sulforaphane (SFN) and fumaric acid esters like dimethyl fumarate (DMF), demonstrated in vitro efficacy but failed to reach advanced clinical translation

This can be especially beneficial in treating conditions characterized by joint degeneration and loss of cartilage

J Biol Chem 278, 4096740972 (2003)

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Estetrol modulates endothelial nitric oxide synthesis in human endothelial cells