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The authors express their sincere gratitude to the Universitas Andalas Institute for Research and Community Service (LPPM) for funding this research under Contract Number: 184/UN.16.19/PT.01.03/PTM/2025 dated September 6, 2024

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In moderate to severe OA, managing systemic inflammation can provide meaningful symptomatic relief even when structural changes cannot be reversed

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Future research should focus on understanding how the regulation of this mixed cell death affects cardiac energy metabolism

Finally, it is also accepted that emotional stress (see Brain Behav Immun 2009, 23, 1089-1095), tobacco smoke (see J Investig Dermatol Symp Proc 2009, 14, 53-55), air pollution, and certain medications (e.g., corticosteroids) (see Clin Exp Dermatol 1991, 16, 416-419) have an adverse effect on the skin and lead to changes (e.g., decreased formation and/or increased degradation) of collagen and other extracellular matrix components