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Zhao Y, Gu Y, Qi F, et al

Med Hypotheses (2015) 85(6):8469

Mecanismo 1

Macrophages exhibit two main phenotypes: M1 (classically activated) and M2 (alternatively activated) (60, 61)

Expression levels of pro-fibrotic markers (pro-collagen I1 and III1) followed a similar pattern: upregulation in the iron overload group and normalization in the amlodipine-treated group (Figure 3H)