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Ming et al

Med Hypotheses 82:428432

doi: 10.1016/j.ijbiomac.2020.08.222 101 MbembaF.HoubionA.RaesM.RemacleJ

Metformin acts by increasing cellular AMP-activated protein kinase (AMPK), thereby enhancing peripheral insulin sensitivity and suppressing hepatic gluconeogenesis and glycogenolysis (Alshehri et al