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While there is research showing that GH treatment can result in the reduction of fine lines and wrinkles by promoting collagen growth and repair of skin tissue, a review by Bartke A et al into growth hormone and aging concluded that elevation of GH levels into the supranormal (pathological) range is associated with increased disease risks and reduced life expectancy likely representing an acceleration of aging [17]

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They discovered that depleting the iSPNs of TrkB signalling leads to increased striatal dopamine due to an increase in the number of dopaminergic cells in the midbrain dopaminergic areas switching from a low dopamine-producing state to a high dopamine-producing state, resulting in striatal neuron vulnerability and motor dysfunction

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