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Furthermore, rescue experiments with antioxidant N-acetylcysteine (NAC) showed that the expression of 4-HNE and the apoptosis in SGNs were significantly decreased, while the number of surviving SGNs was increased in peroxynitrite + NAC group compared the peroxynitrite-only group and in peroxynitrite + gpx1 / + NAC group vs

We explain why the experimental data imply that MMAs acid inhibits the second methylation step

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Finally, pharmacological targeting of the activity of -glutamyltransferases prevents the breakdown of circulating GSH, reduces tumour cysteine levels and slows tumour growth