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The anecdotal reports and animal studies make these peptides seem like a miracle cure, but there are no large-scale human clinical trials or reputable data to support that claim

Recent studies have shown that Chuanxiong rhizome and its extracts can increase the BBB permeability by down-regulating the expression of P-gp, Claudin-5 and occludin, thus promoting the passage of drugs across the BBB [147] ( Fig

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Surgery Prior to elective surgery with general anesthetics, therapy with clomipramine should be discontinued for as long as is clinically feasible, and the anesthetist should be advised

The quality of supplements can also vary

p28 immunoprecipitation of p53, p63, and p73 Immunoprecipitation assays determined in identical cell lysates confirm computerized predictions (Figure 1) and AFS results with recombinant proteins (Figure 4AF, Table 1)