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However, FRDA iPSC-based cells had functional mitochondria and functional secretion of glucose-induced insulin ( Therapeutic solutions for Friedreichs ataxia with the help of induced pluripotent stem cell-based technologies Heterochromatin formation around the FXN gene is the major reason for the downregulation of the FXN gene in FRDA ( FXN gene ( in vitro models ( FXN levels along with a decrease in oxidative stress response ( FXN reporter system revealed HDAC inhibitors as the only compounds that could upregulate FXN levels ( Recent advances in genome editing enabled the correction of expanded alleles in FRDA

doi: 10.30574/gscarr.2024.18.3.0096 92

its presence in endothelial cells of the blood-brain barrier may contribute to the maintenance of concentration of ascorbate in the brain (Li and Schellhorn, Mechanisms of entry into enterocytes Both ascorbate and DHA can enter enterocytes via SVCT and GLUT transporters, respectively

As a result, selenium deficiency increases the risk of hypothyroidism, Hashimotos thyroiditis, and nodular disease

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