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Over-expression of genes associated with MAPK downstream JNK Pathway, in APAP, treated group (G 0 ) is the result of increased oxidative stress and cellular damage in organ, while a protective effect was observed in moringa-(G 3 ) and silymarin-treated group (G 2 )

[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Tenrio M.C.d.S., Graciliano N.G., Moura F., de Oliveira A.C.M., Goulart M.O.F

10.1016/j.bbrc.2017.04.044 161

Efficacy and Safety of Sulforaphane for Treatment of Mild to Moderate Depression in Patients with History of Cardiac Interventions: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

To evaluate the therapeutic efficacy of LXR inverse agonists in vivo, we used three different dysmetabolic rodent models, including high-fat diet (HFD)-induced obese (DIO) mice, HFD-fed Zucker diabetic fatty (ZDF) rats and HFD-fed SpragueDawley (SD) rats (Extended Data Fig