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We also describe various applications and advantages of this Cys-targeted proteomics method and alternative approaches to overcome potential limitations of this method in studying oxidized proteins from MDMA-exposed tissues

10.1021/acsnano.2c09593 42 HuangL.LiuG

Ultimately, these factors create a vicious cycle that contributes to HF

Furthermore, to robustly quantify the transcriptomic similarity between tumor cells and myeloid cells, we calculated at single cell resolution multiple metrics, including Manhattan and Euclidean distance metrics, the Cosine and Pearson correlation-based directional similarity metrics, as well as the Phi and Bray-Curtis proportionality and compositional dissimilarity metrics 22,23

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Therefore, therapeutic strategies that manipulate ROS levels, either by increasing oxidative stress to promote cell death or by targeting antioxidant pathways to inhibit tumor growth, are being explored 118