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Both NAC and cysteine have limited ability to cross the blood-brain barrier (BBB) [111]

In practice, the challenge is rarely just "can GSH react?"it is whether the conjugation route will give the desired attachment site, manageable impurity profile, acceptable stability, and data that clearly distinguish the target product from free glutathione, oxidized material, and positional isomers

A comparison of pathophysiology in humans and rodent models of subarachnoid hemorrhage

They found that knockdown of ZIP8 reduced transport in both directions, while knockdown of ZIP14 specifically affected the basolateral-to-apical transport