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doi: 10.1111/myc.12758 389 ShakibPAliASMJavanmardEMardanshahOMohagheghMAZivdariMet al

10.1111/j.1600-079X.2009.00709.x J

Furthermore, amino acids are closely linked to key anabolic cell signaling pathways, like the mTOR pathway (ONeill et al., 2016)

185 RANKL is produced both as a transmembrane protein and in a soluble form but the membrane-bound form appears to be responsible for the majority of osteoclast formation under normal conditions whereas the soluble form was found to promote cancer cell metastasis to bone in mouse models

Results also evidenced that kava extract and kavalactones possess a week induction on P-glycoprotein ATPase activity