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Maeda N, et al

10.1038/ncb885 118 VasiukovG.NovitskayaT.ZijlstraA.OwensP.YeF.ZhaoZ.et al (2020)

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This dosage showed the potential to trigger an elevation in the number of mitochondria and upregulation in the expression of the Ucp2 gene, which has a crucial role in regulating the mitochondrial processes associated with energy balance to prevent excessive weight gain

This group also studied mice with doxorubicin-induced cardiomyopathy and found that ferroptosis played an important role, possibly because doxorubicin upregulates HO-1, releasing free iron and leading to the generation of oxidized lipids in the mitochondrial membrane