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Overexpression of HSP70 in mice with mutant FUS protein is accompanied by a mitigated neurodegeneration in limbic system

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Such a non-protein cofactor is known as a "prosthetic group." R -lipoic acid functions as a prosthetic group for the biological activity of the following multienzyme complexes: The glycine cleavage system that catalyzes the decarboxylation of glycine coupled with the addition of a methylene group (-CH 2 ) to tetrahydrofolate to form 5,10-methylene tetrahydrofolate, an important cofactor in the synthesis of nucleic acids ( Figure 3 )

Lee DH, Blomhoff R, Jacobs DR Jr

The pool of reduced glutathione (GSH) is fueled by glutathione reductase (GR) activity, which catalyzes the reduction of glutathione disulfide (GSSG) to two molecules of GSH by electron transfer from NADPH