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Strains in which both pathways are disrupted show a significant growth defect connected with the reducing pathways being required for other cellular processes e.g

Abbreviations GPCRs: G protein-coupled receptors PC: Plasma cell MS: Multiple sclerosis BM: Bone marrow CXCR: CXC chemokine receptor CXCL: CXC chemokine ligand S1P: Sphingosin-1-phosphate Ggg: S-geranylgeranyl-L-glutathione CCR: CC chemokine receptor CCL: CC motif chemokine HEV: High endothelial venule LN: Lymph node GC: Germinal Center

Yet, most human IBPs are facultative IBPs, i.e., they are able to grow extracellularly as well as intracellularly

Int J Mol Sci 20(23):5896 McGrath EP, Centonze FG, Chevet E, Avril T, Lafont E (2021) Death sentence: the tale of a fallen endoplasmic reticulum

Chen X, Chen H, Zhu L, Zeng M, Wang T, Su C, Vulugundam G, Gokulnath P, Li G, Wang X, Yao J, Li J, Cretoiu D, Chen Z, Bei Y