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Targeting the BCAAs transporter SLC7A5 with JPH203 inhibited oxidative phosphorylation and exerted anti-leukemic effects, suggesting that the GPRC5C-SLC7A5-BCAAs axis may serve as a therapeutic target (Zhang Y

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In: Benzie IFF, Wachtel-Galor S (eds) Herbal medicine: biomolecular and clinical aspects

Additionally, disproportionality analysis was performed at the PT level, as presented in Table 3

The "No DAC" designation distinguishes this variant from CJC-1295 with DAC (Drug Affinity Complex), which has an extended half-life

Overall, this study advances mechanistic understanding of Pb toxicity in phototrophs by explicitly linking metal accumulation patterns with oxidative stress dynamics and metabolic adaptation in a comparative framework