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Neuroinflammation, a silent driver of sleep fragmentation , is suppressed through anti-cytokine activity of stem cells, particularly by reducing levels of IL-6 and TNF-

HIF-1 (hypoxia-inducible factor-1) promotes macrophage necroptosis by regulating miR-210 and miR-383

Notably, treatment with ferroptosis inhibitors improved cardiac function and previous research suggests that activating or inhibiting Hmox1 can respectively enhance or reduce cardiac ferroptosis (122)

Current animal models testing hydrogel-based brachytherapy Preclinical investigations in rodent and larger animal models have established the safety and multifunctional potential of hydrogel-assisted brachytherapy, demonstrating consistent organ-at-risk separation and reduced radiation injury to the bladder, rectum, and bowel [177, 178]

Another study reported that PINK1 phosphorylated MFN2 at Thr111 and Ser442 to induce MFN2 association with parkin and cause ubiquitination and subsequent degradation of MFN2 ( ATP13A2 ATP13A2 encodes the lysosomal multiple transmembrane P5B-type cation-transporting ATPase ATP13A2

PLoS One 5(11):e15074, 2010