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IKBKE regulates angiogenesis by modulating VEGF expression and secretion in glioblastoma

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SELPLG proteins have two post-translational modifications for their high affinity binding activity, namely tyrosine sulfation and the addition of sialyl Lewis (Lewis) x tetrasaccharides (sLex) to their O-linked glycans

doi: 10.1016/j.ejphar.2020.173701

Although the brain only accounts for 2% of body weight (Mergenthaler et al., 2013) and mitochondrial density is higher in myocytes than in neuronal cells (Gandhi and Abramov, 2012), it is an organ with a high metabolic rate that can consume up to 20% of the total oxygen of the body (Moreira et al., 2009

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