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10.1002/adhm.202400717 57 LuoH.WangZ.HeZ.LingZ.WangH.ZhuJ.et al (2023)

Mechanism of Action IGF-1 DES exerts its anabolic and metabolic effects through high-affinity binding to and activation of the IGF-1 receptor (IGF1R), a receptor tyrosine kinase that is widely expressed across virtually all cell types in the body and serves as the primary mediator of IGF-1's growth-promoting, anti-apoptotic, and metabolic actions

The ferroxidase hephaestin but not amyloid precursor protein is required for ferroportin-supported iron efflux in primary hippocampal neurons

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After endothelial passage IGF-I redistributes to soluble IGFBPs in the extravascular fluids or IGFBPs bound on extracellular matrix or cell surfaces (111)