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This profile not only involves high levels of PAI-1 and STAT3 as previously described, but also includes low levels of glutamine and NAD + , coupled with overproduction of hyaluronan (HA)

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Pharmacological management Carbonic anhydrase inhibitors: acetazolamide and methazolamide Acetazolamide: Currently, acetazolamide treatment is considered one of the most effective pharmacological strategies for CMS treatment

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