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There is greater incidence near the equator

However, the ideal frequency can vary based on the severity of the deficiency and your response to treatment

References Neagu N, Conforti C, Agozzino M, Marangi GF, Morariu SH, Pellacani G, Persichetti P, Piccolo D, Segreto F, Zalaudek I, Dianzani C

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Furthermore, a meta-analysis based on RCTs provided high-level evidence indicating that this combination regimen significantly improved clinical efficacy while effectively reducing the recurrence rate and incidence of adverse reactions in ulcerative colitis patients, highlighting its notable advantage in toxicity reduction ( The clinical benefits outlined in Figure 1 are further corroborated by accumulating data