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10.1038/cti.2016.17 364

JAK/STAT: Why choose a classical or an alternative pathway when you can have both

115,116 There is a clear negative correlation between elevated HCy levels and brain and cognitive function

In smokers, the levels of inflammatory cytokines such as TNF- and IL-6 are elevated, which stimulates osteoclast activity and accelerates bone resorption 26,27