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These disruptions are associated with disease subtypes, progression rates, and clinical outcomes (334, 335, 338354, 358), and studies have shown that iron chelation therapy can delay motor neuron degeneration and extend survival in ALS mouse models (352, 355, 358) ( Figure 8 )

Other factors, that may independently increase the risk of tendon rupture include strenuous physical activity, renal failure, and previous tendon disorders such as rheumatoid arthritis

For the delayed therapy, intraocular pressure was assessed as described above, at 48 h postL-NAME administration, before medication application, and thereafter at described intervals

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