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Polymers like poly(N-isopropylacrylamide) (PNIPAM) transition from a hydrophilic to a hydrophobic state at their lower critical solution temperature (LCST), leading to drug release [305]

RC reports consulting and lecture fees from Astellas, Akern, Baxter, B-Braun, Bristol-Myers Squibb, Boehringer Ingelheim, Eli Lilly, Fresenius Kabi, Lionhealth, Nestl Health Science, Novartis, Nutrisens, MSD, Nutricia, Pfizer, Roche, Servier, Takeda, Viatris, all outside the submitted work

The ATP-depleting futile 5-oxoproline cycle can also contribute to other acute and chronic acetaminophen toxicity syndromes

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