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However, under stress conditions, modifications of KEAP1 disrupt this interaction, allowing NRF2 to accumulate and translocate into the nucleus

Jul 2020;16(3):401-407

H.ZennadiR.LeitgebA.et al (2016)

- Passes through the blood-brain barrier - Supports cognitive health & optimal brain function

This restoration of tissue function could also be accompanied by a reduction in the biomarkers associated with cellular aging, suggesting a return toward a more balanced state of cell function