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doi:10.1007/s10096-019-03660-6 Dahl EH, Mosevoll KA, Cramariuc D, Vedeler CA, Blomberg B

When you swallow a B12 pill, several steps have to work for it to be absorbed: stomach acid and the enzyme pepsin must release B12 from food or the supplement, the stomach must secrete a protein called intrinsic factor that binds to B12, and the B12-intrinsic factor complex must reach the ileum (the end of the small intestine) where it is finally absorbed