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Br Poult Sci 51:132141 Kiemer AK, Mller C, Vollmar AM (2002) Inhibition of LPS-induced nitric oxide and TNF- production by -lipoic acid in rat Kupffer cells and in RAW 264.7 murine macrophages

Note that we analyzed RPE1 cells in the current study and not HeLa cells, and perfect overlap is therefore not to be expected due to significant differences in protein abundances and hence phospho-signaling network activities between cell lines 23

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It is important to note that the effect of ROS in circulating or infiltrating immune cells depends on the site of production, especially in case of autoimmunity where ROS induce Treg activation while limiting T cell proliferation and cytokine production [108,109,110,111], resulting in dampened disease activity