However, as with any procedure, there may be certain risks and complications such as: Infection at the injection site Reaction at the injection site Pain or swelling at the injection site Septic arthritis Acute arthritis Inflammation of the joint lining Nerve Injury Summary Intra-articular knee injections are a safe and effective procedure to treat pain from conditions such as osteoarthritis and rheumatoid arthritis

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No severe headaches were reported, and no participant discontinued due to this symptom
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