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NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for IronSulfur Cluster Proteins

Proc Latv Acad Sci B Nat Exact Appl Sci

This study, using single-cell analysis, was the first to reveal a connection between selinexor resistance and ferroptosis evasion in CML, suggesting a novel strategy to reverse drug resistance through ferroptosis induction in hematological malignancies such as MM ( Venetoclax, a BCL-2 inhibitor, promotes apoptosis in tumor cells

Furthermore, the mRNA levels of cGAS , STING , p-IRF3 , and IFN were markedly increased following mtDNA treatment (Figure 7B)

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