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Blood-based gene expression signatures of infants and toddlers with autism

The main cellular antioxidant GSH, whose regeneration depends on the PPP, is also released by astrocytes and alters the synaptic response by modulating the redox and non-redox sites of ionotropic receptors and ion channels

10.1016/j.freeradbiomed.2025.03.031 143 ShiJ.JiX.ShanS.ZhaoM.BiC.LiZ

Thus, with pathologic HNE concentrations (10M and higher) for rat GCLC, ERK activation was required for the HNE-mediated induction but for human GCLC, JNK activation was essential and Nrf2 was not required (Iles and Liu, 2005)