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Figure 6 Trichothecenes are small molecular inhibitors of protein synthesis and trigger ribotoxic stress by binding to the peptidyl transferase site of the large 60S subunit of eukaryotic ribosomes (Garreau De Loubresse et al., 2014)

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& Hadwan, M.H

Therefore, to reduce the ROS activity, host cells are evolved with three types of SODs such as NiSOD, Fe or MnSOD, and CuZnSOD to control the ROS activity produced by itself

Two key regulators of mitochondrial biogenesis, namely, proliferator-activated receptor gamma coactivator 1- and nuclear respiratory factor 1, which are responsible for mitochondrial DNA transcription, are under the control of Nrf2 (Piantadosi et al., 2008

This may provide guidance for the clinical application of L